Worst Week is an American sitcom television series that premiered on CBS on September 22, 2008. The series was based on the British sitcom The Worst Week of My Life. It was adapted for American audiences by Fox under the title Worst Week of My Life, but a series didn't materialize after the pilot was filmed.

The series aired on CBS Mondays at 9:30pm ET/PT, following Two and a Half Men. The premiere attracted 11 million viewers but lost a third of its lead-in audience. Ratings dropped to a low of 8.4 million viewers with the sixth episode, but then began to climb steadily, reaching a high of 12.12 million viewers with the eleventh episode before declining again.

On May 20, 2009, CBS cancelled the series after one season and the series finale aired on June 6, 2009.