What's with Andy? (French: Sacré Andy!) is an animated children's television series loosely based on the semi-autobiographical Just! book series by Australian author Andy Griffiths. The series is produced by CinéGroupe and aired on Teletoon, with various Disney-affiliated foreign studios and networks involved throughout the production of the series.

The main character is Andy Larkin, a mischievous teen and the self-proclaimed "world's greatest prankster". The show follows him as he tries to perform elaborate practical jokes, or pranks, on people in the fictional town of East Gackle, as his best friend, Danny Pickett, helps him out with almost every prank; his antagonists include: his older sister, Jen Larkin; and the bullies Peter Lik and Andrew Leech. He has a crush on a girl named Lori Mackney, whom he usually tries to impress.

The first season features an American cast of voice actors (with the exception of Canadian-born Ian James Corlett) and takes place in the United States. However, starting with the second season, all voice actors and screenwriters are Canadians and the show is set in the Canadian Prairies. Throughout the series, Andy often breaks the fourth wall to address the audience, with the screen freezing in black and white in the first season – a distinctive feature of the show referred to as "Doodle Vision".