The Larry Sanders Show is an American television sitcom set in the office and studio of a fictional late-night talk show. The series was created by Garry Shandling and Dennis Klein and aired from August 15, 1992, to May 31, 1998, on the HBO cable television network.

The series stars Shandling, Jeffrey Tambor, and Rip Torn and features celebrities playing exaggerated, parodic versions of themselves. The show has its roots in Shandling's stand-up comedy background, his experience as a guest host on The Tonight Show, and his earlier sitcom It's Garry Shandling's Show. The program has had a marked and long-lasting influence on HBO as well as on television shows in the US and UK such as Curb Your Enthusiasm, 30 Rock, and The Office. The supporting cast includes Janeane Garofalo, Wallace Langham, Penny Johnson, Linda Doucett, Scott Thompson, and Jeremy Piven.

The show received universal acclaim from critics and is often regarded as an influential and landmark series. It ranked 38 on TV Guide's 50 Greatest TV Shows of All Time, the only HBO comedy to make the list, and was also included in Time magazine's list of the "100 Best TV Shows of All Time". The show won 24 major awards, including three Primetime Emmy Awards, five CableACE Awards, four American Comedy Awards, two British Comedy Awards, two Peabody Awards, a BAFTA Award and a Satellite Award. It also received 86 nominations, including 56 Primetime Emmy Awards nominations, five Directors Guild of America nominations, six Writers Guild of America nominations, six American Comedy Awards nominations, three Golden Globe nominations, three Satellite Awards nominations and a GLAAD Award nomination.