Wipeout is an American television game show that features contestants competing in (what was billed as) the "World's Largest" obstacle course which originally aired on ABC from June 24, 2008, to September 7, 2014. In 2021, the show was rebooted on TBS, with John Cena, Nicole Byer, and Camille Kostek as hosts.

The show was originally hosted and commentated by John Henson and John Anderson, while Jill Wagner acted as the "on-location" reporter. The interim reporter for one season was Vanessa Lachey. The creators and executive producers are Matt Kunitz and Scott Larsen. Distribution of the show was handled by Endemol Shine. The show was taped at Sable Ranch in Canyon Country, California, north of Los Angeles.