Tyler Perry's House of Payne, also known as simply House of Payne, is an American sitcom television series created and produced by Tyler Perry that premiered in syndication on June 21, 2006.

The series revolves around a multi-generational family living under one roof in Atlanta led by patriarch Curtis Payne and his wife Ella. While primarily a comedy, with elements of slapstick, House of Payne was known for featuring dark themes and subject matter, such as substance abuse and addiction. The show is also heavily serialized, with many references to past episodes, creating a continuing story arc.

Reaching 254 episodes upon the conclusion of its sixth season, House of Payne has aired more episodes than any other television series with a predominantly African American cast, surpassing The Jeffersons with 253 episodes, Family Matters with 215 episodes, and The Cosby Show with 202 episodes. The show currently has over 362 episodes.