Loonatics Unleashed is an American superhero animated television series produced by Warner Bros. Animation that ran on Kids' WB for two seasons from 2005 to 2007. It also aired on Cartoon Network internationally (excluding Japan). The series was based/inspired on the Looney Tunes cartoon characters, with the series described by Warner Bros. as an action comedy. Loonatics Unleashed is meant to be a mixture of the Looney Tunes shorts' irreverent style of humor and a modern action animated series, with the characters designed in a more action cartoon-inspired style.

Unlike previous Looney Tunes-related shows, Loonatics Unleashed has a darker tone and takes place in a post-apocalyptic setting, following multiple minor story arcs. The initial concept designs were met with backlash among fans and there were petitions to have the designs changed, while Sander Schwartz defended the show's direction, saying "the classic characters were just “sharing DNA” with these new ones and it was merely an extension of the franchise." Sam Register, who became WB's executive vice president of creative affairs in 2008, considers the character designs "a reminder of what not to do". This serves as the final series of the Looney Tunes TV franchise to premiere in the 2000s decade. After Loonatics Unleashed ended, the franchise would go on hiatus until the release of The Looney Tunes Show on Cartoon Network, four years later.