Uncle Grandpa is an American animated television series created by Peter Browngardt for Cartoon Network that ran from September 2, 2013, to June 30, 2017. It is based on Browngardt's animated short of the same name from The Cartoonstitute. Uncle Grandpa is also a spin-off of Secret Mountain Fort Awesome, which was in turn a spin-off of The Cartoonstitute short. It was produced by Cartoon Network Studios.

The show is a surreal action-adventure comedy that relies extensively on visual gags and catchphrases. Creator Pete Browngardt has cited the work of cartoonists Virgil Partch, Don Martin, Harvey Kurtzman, Gary Larson and Robert Crumb, as well as Golden Age–era animators such as Tex Avery and Max Fleischer when it came to developing the style of the show. Each 11-minute episode is presented in a unique format, consisting of a main seven to nine-minute story, some short bumpers typically composed of a quick visual joke, and an original short that focuses on the show's side characters.

Cartoon Network renewed the series for the fourth and fifth seasons: first splitting the second season (of 52 episodes) into two halves, which respectively became the second and third season, then dividing in half the already announced third season into the fourth and fifth season (of 26 and 23 episodes, respectively), which served as the final seasons.

The series premiered on Cartoon Network on September 2, 2013. While the pilot was nominated in 2010 for a Primetime Emmy Award in the category of Outstanding Short-Format Animated Program, the show itself was awarded in 2014 for the work of Nick Edwards in the category of Outstanding Individual in Animation. Kevin Michael Richardson was also nominated for a Annie Award in 2016 in the category of Best Voice Acting for an Animated TV/Broadcast Production for his work as Mr. Gus in the show. The show on itself received mixed reviews from critics by the time of its release, with praise toward the show's animation and visual humor, while also receiving criticism for its pacing. Retrospective reviews have been more positive, especially after the release of Browngardt's Looney Tunes Cartoons (which he developed), with critics and viewers alike praising its concept, humor, deranged animation and overall tone.