The Defenders is an American legal comedy-drama television series that was ordered to series by CBS for the 2010–11 television season. The series originally ran from September 22, 2010, to March 11, 2011. Set in Las Vegas, Nevada, the show involves a pair of defense attorneys who go all out to help their clients while keeping their personal lives in order. The show is loosely based on real-life Vegas lawyers Michael Cristalli and Marc Saggese. This series is not related to the 1960s CBS series of the same name.

In October 2010, CBS announced that the show had been picked up for a 18-episode season with the option to produce a full 22-episode season. In January 2011, CBS announced that The Defenders was moving from its Wednesday timeslot to the Friday timeslot vacated by Medium which aired on NBC and then CBS for seven seasons, with Blue Bloods temporarily moving to the timeslot The Defenders vacated. Blue Bloods returned to its Friday timeslot in February 2011 owing to the series premiere of Criminal Minds: Suspect Behavior. The Defenders aired the last six episodes of its season on Fridays at 8:00 p.m. Eastern/7:00 p.m. Central. Jim Belushi and Jerry O'Connell star as the defense attorneys of the show's title.

On May 15, 2011, CBS canceled the series after one season.