He-Man and the Masters of the Universe is an animated television series. Developed for television by Michael Halperin, who created the original series, it was animated by Mike Young Productions. It served as an update of the 1980s Filmation series, produced to coincide with Mattel's revival of the Masters of the Universe franchise eleven years after its previous attempt. The series ran on Cartoon Network's Toonami programming block between August 16, 2002, and January 10, 2004.

Unlike the previous He-Man series, set on the futuristic planet of Primus, this version sought to return to the roots of the storyline and provide broader explorations never reached in the first series, including origins for each character, and some first-time animated debuts of familiar toyline faces. The series also brought back several writers from the original series, such as Larry DiTillio and Michael Reaves. Also, it is the second and final He-Man series to feature a Canadian voice cast with the exception of Cam Clarke.

The series has been noted for similarities it shares with the original series. For example, it has an homage intro to the Filmation series' intro speech, but in this version, teenager Prince Adam is interrupted by an explosion and invasion by Skeletor and his henchmen. Prince Adam transforms into He-Man when he says "By the power of Grayskull... I have the power!" (later episodes feature a chorus singing He-Man's name during the scene change). It also features "scene change" sequences, but only the one involving the Sword of Power was taken from the Filmation series; all the others were created for this series, and the sequences occur less frequently than on the previous series.