Los Serrano is a Spanish television drama comedy which premiered on 22 April 2003 and aired on Telecinco. It tells the story of the Serrano family, who lives in Round Santa Justa No 133, located in the fictional neighborhood of Santa Justa, in the Ribera del Manzanares, in Madrid. It was produced by Globomedia for Telecinco.

The series was a pioneer in introducing a new family model as well as being at the peak and suiting to new social currents. The origin of the plot focuses on coexistence and the differences between men and women in the same house.