Space Ghost Coast to Coast is an American adult animated comedy late-night talk show created by Mike Lazzo for Cartoon Network and hosted by a re-imagined version of the 1960s Hanna-Barbera cartoon character Space Ghost. It is the first TV show to be produced by Williams Street (formerly known as Ghost Planet Industries), the company to start up Adult Swim in the early 2000s. In contrast to the original 1960s series, Space Ghost, which aired as a standard Hanna-Barbera Saturday-morning superhero cartoon, Space Ghost Coast to Coast is a reboot and sequel of the series intended for teens and adults, reinterpreted as a surreal spoof talk show and animated using the original series' artwork. Early seasons are more of a parody of late-night talk shows, while later seasons rely more on surrealism and non-sequitur humor.Space Ghost Coast to Coast is the first original series fully produced by Cartoon Network. It premiered on April 15, 1994, and originally ended on December 17, 1999. The series was revived on May 7, 2001, and was moved to the then-new Adult Swim late-night programming block on September 2, where new episodes premiered until April 12, 2004. Two final seasons were released exclusively on GameTap from 2006 to 2008. Over 11 seasons, 109 episodes aired. The series helped to launch the careers of animators Adam Reed, Matt Thompson, Andy Merrill, Jim Fortier, Pete Smith, Michael Ouweleen, Erik Richter, Dave Willis, and Matt Maiellaro.

Six spin-off series, Cartoon Planet, Toonami, The Brak Show, Aqua Teen Hunger Force, Perfect Hair Forever, and Harvey Birdman, Attorney at Law, are based on Space Ghost: Coast to Coast. The series has also inspired or influenced other series for Adult Swim, including Sealab 2021 and The Eric Andre Show.