The 2010 Extreme Rules was the second annual Extreme Rules professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. The event took place on April 25, 2010, at the 1st Mariner Arena in Baltimore, Maryland. It replaced Backlash as the post-WrestleMania pay-per-view. It was the first Extreme Rules event to feature the titular Extreme Rules match and the last WWE PPV to feature a Saliva song which was "Time to Shine".

The concept of Extreme Rules is that the event features various hardcore-based matches. There were eight matches scheduled on the event's card, all of which were contested under a hardcore stipulation. There was also one dark match that occurred before the live broadcast. In the main event, John Cena defeated Batista in a Last Man Standing match to retain Raw's WWE Championship. In SmackDown's main match, which was an interpromotional match, Jack Swagger defeated Raw's Randy Orton in an Extreme Rules match to retain the World Heavyweight Championship. The event received 182,000 pay-per-view buys, the same as the figure achieved by the 2009 Backlash event.