Vic Reeves Big Night Out is a cult British comedy stage show and later television series which ran on Channel 4 for two series in 1990 and 1991, as well as a New Year special. Its live incarnation marked the beginnings of the collaboration between Vic Reeves (real name Jim Moir) and Bob Mortimer and started their Reeves and Mortimer (also known informally as Vic and Bob) comedy double act.

The show was later acknowledged as a seminal force in British comedy throughout the 1990s, the influence of which continued long afterward.Arguably the most surreal of the pair's work, Vic Reeves Big Night Out was effectively a parody of the variety shows which dominated the early years of television, but which were, by the early 1990s, falling from grace. Vic, introduced by Patrick Allen as "Britain's Top Light Entertainer and Singer", would sit behind a cluttered desk talking nonsense and introducing the various segments and surreal guests on the show. Vic Reeves Big Night Out is notable as the only occasion in their career in which Vic took the role of sole host, while Bob was consigned to the back stage, appearing every few minutes as either himself or as a strange character. The two received equal billing in the series credits.

On 3 October 2007, the first episode was re-broadcast on More4 as part of Channel 4 at 25, a season of classic Channel 4 programmes shown to celebrate the channel's 25th birthday.

On 25 October 2009, repeats of Big Night Out began running on TV channel Gold.

Both series of the show and the New Year's Special are currently available for viewing on Channel 4's streaming service, All 4.