Brainiac: Science Abuse (often shortened to simply Brainiac) is a British entertainment documentary show that aired on Sky One from 13 November 2003 to 30 March 2008. It was created by Executive Producer Stewart Morris and Andy Milligan. During each episode of the show, numerous experiments are carried out to verify whether common conceptions are true (such as whether it is possible to run across a pool of custard) or simply to create impressive explosions. The experimenters on the show are referred to as "Brainiacs", and each episode usually finishes with the destruction of a caravan.

The original presenters were Richard Hammond and Jon Tickle, who were joined in the second series by Charlotte Hudson. Hammond and the original production team left after the fourth season, and was replaced by Vic Reeves and Hudson left after the fifth, and was replaced by Thaila Zucchi. On 28 July 2008 Sky cancelled the show saying it had been taken as far as it could go.