American Dad! is an American animated sitcom created by Seth MacFarlane, Mike Barker and Matt Weitzman for the Fox Broadcasting Company. The series moved to TBS for its twelfth season in 2014 and continues to air new episodes to this day. American Dad! is the first television series made to premiere on Fox's Animation Domination block. The series premiered on February 6, 2005, following Super Bowl XXXIX, with the rest of the first season airing from May 1, 2005.

Creative direction of American Dad! had largely been guided by Barker (prior to his departure from the show in season 10) and Weitzman as opposed to MacFarlane, resulting in a series that is different from its counterparts. Unlike MacFarlane's other shows, Family Guy and, to a lesser extent, The Cleveland Show, American Dad! does not lean as heavily on the use of cutaway gags, and is less concerned with conventional "setup-punchline" jokes, instead deriving its humor mostly from the quirky characters, the relationships between family members, and the relatively relatable plots. While the core issues and resolutions are relatable in most episodes, the show nonetheless weaves in fantastical elements, pitching the tone of the show somewhere between observational comedy and farce. The plots are often absurd, but grounded by family stories and real-world issues.

American Dad! has been nominated for numerous awards, including four Primetime Emmy Awards and two Annie Awards. In June 2013, it was awarded as top television series by the American Society of Composers, Authors and Publishers. Since its debut, American Dad! has broadcast 386 episodes (as of March 10, 2025). The total number of seasons and organization of episodes within those seasons are in dispute due to discrepancies in how official sources report this information. One model suggests the first season of American Dad! comprises the first seven episodes, while another model suggests the first season comprises 23 episodes.

Beginning on October 20, 2014, TBS picked up the series for the 12th season following the final three episodes airing on Fox as the 11th season. TBS, TruTV, and Adult Swim, (all owned by Warner Bros. Discovery), air reruns of the series. On December 16, 2021, the series was renewed for seasons 20 and 21. The 20th season premiered on March 27, 2023. The 21st season premiered on October 28, 2024.