Wagon Train is an American Western television series that aired for eight seasons, first on the NBC television network (1957–1962) and then on ABC (1962–1965). Wagon Train debuted on September 18, 1957 and reached the top of the Nielsen ratings. It is the fictional adventure story of a large westbound wagon train through the American frontier from Missouri to California. Its format attracted famous guest stars for each episode appearing as travelers or residents of the settlements that the regular cast encountered.

The show initially starred film actor Ward Bond as the wagon master (replaced after his death in 1960 by John McIntire) and Robert Horton as the scout (eventually replaced by Robert Fuller).

The series was inspired by the 1950 film Wagon Master and the 1930 early widescreen film The Big Trail, both featuring Bond. The series influenced the development of Star Trek, pitched as "Wagon Train to the stars" and launched in 1966.