Heavy Rescue: 401 is a Canadian reality television show that follows the operations of multiple heavy vehicle rescue and recovery towing companies, as well as the Ontario Provincial Police (OPP), Ministry of Transportation of Ontario, and York Regional Police, based in the Greater Toronto Area (GTA) and the Southern Ontario region. The show focuses on the hardships of vehicle recovery along Ontario's Highway 401 and other 400-series highways, frequently in the Greater Toronto Area.

After the success of Highway Thru Hell, series creator Mark Miller developed a spinoff series titled Heavy Rescue: 401, which debuted on January 3, 2017, on Discovery Canada following the October 2016 pilot. The show is produced by Great Pacific Television, and executive produced by Kelly McClugan and Blair Reekie.