Joe Pera Talks with You is an American comedy television series created by Joe Pera for Adult Swim. The show stars Joe Pera as a fictionalized version of himself, a mild mannered choir teacher in Marquette, Michigan, who directly addresses the audience about seemingly mundane, everyday topics such as dance, pancakes, minerals, etc. Diving into these topics, viewers get an introspective glimpse into his slowly changing life in the Upper Peninsula and the interaction with people around him.

The series was produced by Pera’s Chestnut Walnut Unlimited, Cartoon Network Studios’ live-action division (Factual Productions, Inc, and Alive and Kicking, Inc.), and Williams Street. It entered development following the success of the 2016 specials Joe Pera Talks You to Sleep, which was animated, and Joe Pera Helps You Find the Perfect Christmas Tree, airing as part of Infomercials, with the first season premiering on May 20, 2018. The second season premiered on December 6, 2019. A third and final season aired from November to December 2021. In July 2022, Pera announced the show was canceled after three seasons. Reruns aired on Cartoon Network's ACME Night programming block starting from 2023.

Joe Pera Talks with You received critical acclaim, with most praise going to its unique writing, slow-paced and earnest tone, and witty humor; the show's cancellation similarly drew strong reactions and tributes from critics. Screen Rant compares the show's sincere tone favorably to Mister Rogers' Neighborhood, while Vice hailed the show as "the best thing Adult Swim has ever done".