The Oprah Winfrey Show is an American first-run syndicated talk show that was hosted by Oprah Winfrey. The show ran for twenty-five seasons from September 8, 1986, to May 25, 2011, in which it broadcast 4,561 episodes. The show was taped in Chicago and produced by Winfrey. It remains the highest-rated daytime talk show in American television history.

The show was highly influential to many young stars, and many of its themes have penetrated into the American pop-cultural consciousness. Winfrey used the show as an educational platform, featuring book clubs, interviews, self-improvement segments, and philanthropic forays into world events. The show did not attempt to profit off the products it endorsed; it had no licensing agreement with retailers when products were promoted, nor did the show make any money from endorsing books for its book club.

Oprah was one of the longest-running daytime television talk shows in history. The show received 47 Daytime Emmy Awards before Winfrey chose to stop submitting it for consideration in 2000. In 2002, TV Guide ranked it at No. 49 on TV Guide's 50 Greatest TV Shows of All Time. In 2013, they ranked it as the 19th greatest TV show of all time. In 2023, Variety ranked The Oprah Winfrey Show #17 on its list of the 100 greatest TV shows of all time.