The Mighty B! (stylized in all caps) is an American animated television series created by former SNL cast member Amy Poehler, Cynthia True, and Erik Wiese for Nickelodeon. The series centers on Bessie Higgenbottom, an ambitious Honeybee girl scout who believes she will become The Mighty B (a superhero) if she collects every Honeybee badge. Bessie lives in San Francisco with her single mother Hilary, brother Ben and dog Happy. Poehler provides the voice of Bessie, who is loosely based on the character Cassie McMadison, who Poehler played on the improvisational comedy troupes Upright Citizens Brigade and Second City before she joined the cast of Saturday Night Live.

The series ran on Nickelodeon from April 26, 2008, to January 16, 2010, before it was moved to Nicktoons on November 6, 2010, which followed the series' ending on June 18, 2011. Since its debut, the show has attracted an average of 3.1 million viewers. In the second quarter of 2008, the show ranked among the top five animated programs on television.

In September 2008, the show was renewed for a second and final season with 20 episodes that premiered on September 21, 2009.

The Mighty B! was nominated for six Annie Awards and four Daytime Emmy Awards, winning one Daytime Emmy for Outstanding Individual Achievement in Animation. It has garnered one Artios Award nomination and one Golden Reel Award nomination.