Nothing Sacred is an American drama series that aired from 1997 to 1998 on ABC. The series was created by a Jesuit priest named Bill Cain and producer David Manson.

The series centered on the daily goings-on at a parish in an inner-city neighborhood. The show drew criticism from some Catholic organizations for its frank treatment of sensitive issues such as AIDS, racism, and abortion, as well as its portrayal of church issues in the post-Second Vatican Council era, which some saw as favoring those with more liberal views of the Council. The show and its sponsors were targeted for boycotts by the Catholic League. The series faced low ratings and ABC canceled its order for the final four episodes, eventually canceling the series entirely after the March 14, 1998 episode (with five completed episodes left unaired).

The series did win critical acclaim, including a Peabody Award for its "honest portrayal of the complexity of faith in the modern era" and a Humanitas Prize. It also received nominations for Emmy Awards and a Golden Globe Award nomination for actor Kevin Anderson.