Mother Up! is an adult animated sitcom created by Marnie Nir and Katherine Torpey, which premiered on Hulu in the United States on November 6, 2013. The series also begin airing on City in Canada on January 23, 2014. It was developed by Rogers Media and is a co-production between Canadian companies Breakthrough Entertainment and Bardel Entertainment, and U.S.-based Mass Animation. A total of 13 episodes were produced.

The show marked Hulu's second foray into animated programming after The Awesomes. It was pitched as "Family Guy for women".

The Mother Up! theme song, is written and performed by Lee Anna James in the Hulu release, but on the Canadian version, it was written by Warren Bray & Odario Williams of Grand Analog and Maiko Watson, formerly of Sugar Jones.