The John Larroquette Show is an American sitcom television series that was created by Don Reo for NBC. The John Larroquette Show was a star vehicle for John Larroquette following his run as Dan Fielding on Night Court. The series takes place in a seedy bus terminal in St. Louis, Missouri, and originally focused on the somewhat broken people who worked the night shift, and in particular, the lead character's battle with alcoholism. The series was produced by Reo's Impact Zone Productions, Larroquette's Port Street Films and Witt/Thomas Productions in association with Warner Bros. Television.

It premiered on September 2, 1993 and ended on October 30, 1996, with a total of 84 episodes over the course of 4 seasons, although 6 of those episodes were never aired. NBC canceled the series after airing only six episodes in season 4.