Friday Night, Saturday Morning was a UK television chat show with a revolving guest host. It ran on BBC2 from 28 September 1979 to 2 April 1982, broadcast live from the Greenwood Theatre, a part of Guy's Hospital. It was notable for being the only television show to be hosted by a former British Prime Minister (Harold Wilson), and for an argument about the blasphemy claims surrounding the film Monty Python's Life of Brian (1979).

The programme was the idea of Iain Johnstone and Will Wyatt, who insisted on a changing presenter every fortnight. Another innovation was that the presenters chose the guests they were to interview.