Conan O'Brien Must Go is a travel show starring former late-night talk show host Conan O'Brien. The series is a spin-off of his podcast Conan O'Brien Needs a Friend and a successor to his many remotes and the Conan Without Borders travel specials that originally aired as part of his TBS show Conan. Premiering on the streaming service Max in the United States on April 18, 2024, the series features O'Brien meeting various fans in person whom he had previously featured via video calls in his podcast series. In the first season, O'Brien traveled to Norway, Argentina, Thailand, and Ireland. The show received widespread critical acclaim and received an Emmy Award.

In May 2024, the series was renewed for a second season that premiered on May 8, 2025. In the second season, O'Brien traveled to Spain, New Zealand, and Austria. In March 2025, ahead of the second season's premiere, the series was renewed for a third season.