Baby Blues is an American adult animated sitcom, based on the comic strip of the same name by Rick Kirkman and Jerry Scott, produced by Warner Bros. The first eight episodes of Baby Blues originally aired in the United States on The WB between July 28 and August 24, 2000, before being canceled. The five remaining episodes from the first season eventually aired on Adult Swim in 2002. A second season, consisting of 13 episodes, was produced but never aired.

The animated adaptation of Baby Blues differs from the comic by having it take place when Zoe was still an infant, even though she was the older sister to Hammie in the strip at the time. In addition, it focuses on Darryl and Wanda's relationship with supporting characters created for this series, including the Bittermans, a dysfunctional next-door family with three children; Bizzy, Zoe's babysitter; and Kenny, Darryl's laid-back close friend and co-worker.