God, the Devil and Bob is an American animated sitcom which aired on NBC from March 9 to March 28, 2000, leaving nine episodes unaired. It was created by Matthew Carlson. The entire series was released on Region 1 DVD in the United States on January 4, 2005. Reruns of the series began airing on Cartoon Network's late night sister time-sharing network, Adult Swim, on January 1, 2011, with the network airing the nine remaining episodes of the series from January 8 to March 26, 2011.

Thirteen episodes were made, but only four were broadcast in the United States before the series was canceled due to a combination of low ratings and pressure from religious activists, despite receiving mostly positive reviews from critics and audiences alike.

James Garner wrote in his memoirs that "It's a shame we went out of business so soon because I loved playing God."

The show, however, was well received in places such as the United Kingdom, Ireland, and Latin America (including Brazil), where BBC Two, RTÉ, and Fox, respectively, aired the entire series. It was once broadcast on the now-defunct Philippine channel Maxxx.