Snakes on a Plane is a 2006 American action horror film directed by David R. Ellis and starring Samuel L. Jackson. It was released by New Line Cinema on August 18, 2006, in North America. The film was written by David Dalessandro, John Heffernan, and Sebastian Gutierrez and follows the events of dozens of venomous snakes being released on a passenger plane in an attempt to kill a trial witness.

The film gained a considerable amount of attention before its release, forming large fanbases online and becoming an Internet phenomenon, due to the film's title, casting, and premise. In response to the Internet fan base, New Line Cinema incorporated feedback from online users into its production, and added five days of reshooting. Before and after the film was released, it was parodied and alluded to on television shows and films, fan-made videos, video games, and various forms of literature.

Released in the US and UK on August 18, 2006, the film received mixed reviews and was a "box office disappointment". Despite the immense Internet buzz, the film's gross revenue did not live up to expectations; it earned US$15.25 million in its opening weekend. The film grossed US$62 million worldwide before its release on home video on January 2, 2007.