Larry King Live is an American television talk show broadcast by CNN from June 3, 1985 to December 16, 2010. Hosted by Larry King, it was the network's most watched and longest-running program, with over one million viewers nightly.

Mainly aired from CNN's Los Angeles studios, the show was sometimes broadcast from the CNN Center in Atlanta, from the Time Warner Center in New York City, or from Washington, D.C., where King had gained national prominence during his years as a radio interviewer on the Larry King Show for the Mutual Broadcasting System. Every night, King interviewed one or more prominent individuals, usually celebrities, politicians and businesspeople.

The one-hour show was broadcast three times a day in some areas, and was seen all over the world on CNN International.

On June 29, 2010, King announced that the program would end. The final episode aired on December 16, but a new episode on the war against cancer aired two days later on December 18.

Larry King Live was replaced by Piers Morgan Tonight, a talk show hosted by British television personality and journalist Piers Morgan, that began airing on January 17, 2011. It was renamed to Piers Morgan Live in 2013, and ran its last episode on March 28, 2014, after being cancelled. In October 2023, CNN premiered Laura Coates Live; while its host Laura Coates described it as a spiritual successor to Larry King Live (citing her adoration of King's "intimate" style), and the program utilizes graphics inspired by the show, Laura Coates Live utilizes a pundit-based format similar to other CNN primetime programs and is otherwise unrelated.