The High Fructose Adventures of Annoying Orange is an American live-action/animated television series created by Tom Sheppard and Dane Boedigheimer for Cartoon Network. Based on the characters from the web series Annoying Orange, created by Boedigheimer and Spencer Grove, it was produced by Annoying Orange, Inc., The Collective, and 14th Hour Productions. A preview aired on May 28, 2012, and the official premiere was on June 11, 2012. The show ended on March 17, 2014, with two seasons and sixty episodes, with a total of thirty episodes per season.

The series also featured many well-known guest stars such as Mark Hamill, Slash, Kendall Jenner, Jim Parsons, Carly Rae Jepsen, Carlos Alazraqui, Jim Belushi, Matt Bomer, "Weird Al" Yankovic, Rainn Wilson, Seth Green, George Takei, among others.