Life with Derek is a Canadian television teen sitcom that aired on Family Channel (English) and VRAK.TV (French) in Canada and on Disney Channel in the United States. The series premiered on Family on September 18, 2005, and ran for four seasons, ending its run on March 25, 2009. Reruns currently air on Family Channel and previously aired on multiplex sister channel Family Chrgd. The series stars Michael Seater as the titular character and Ashley Leggat as his step-sister Casey. These are the two oldest children in a stepfamily.

It ended having aired 70 episodes, and was followed by one spin-off television film, entitled Vacation with Derek, which was filmed in northern Ontario in fall 2009, and it aired on Family Channel on June 25, 2010.

On May 12, 2020, Shaftesbury Films announced that a spinoff television film, titled Life with Luca and set 15 years after the original series, was in development. The spin-off feature film premiered in February 2023.