Celebrity Juice was a British television comedy panel game broadcast on ITV2 between 24 September 2008 and 15 December 2022. The show was written and presented by Leigh Francis in the role of his alter ego Keith Lemon. The format for the series was first suggested in 2007, after the final series of Francis’s Channel 4 sketch show Bo' Selecta!. ITV approached him to create a show featuring Lemon, and after the success of the five-part series Keith Lemon's Very Brilliant World Tour, the channel commissioned Celebrity Juice. The original premise of the show was to see which team knows most about the week's tabloid news stories, although later series focus more on the comedy factor of the participating celebrity guests and games involving them, rather than discussing the week's news.

Fearne Cotton and Holly Willoughby were the show's original team captains. In December 2018, Cotton announced that she would leave the series after ten years in order to pursue other projects. She was replaced by Paddy McGuinness, though he left after one series and was replaced by Mel B. On 4 May 2020, Willoughby revealed her decision to quit the series after 12 years on the show. She made her final appearance as team captain at the end of the 23rd series. Mel B also departed at the end of series 23. On 10 September 2020, it was announced that Laura Whitmore and Emily Atack had joined the show as team captains. On 29 March 2021, it was announced that Maya Jama had joined the show as a regular panellist. In December 2021, Celebrity Juice became one of three shows by Francis to get recommissioned for 2022, along with ITV2's Shopping with Keith Lemon and the E4/Channel 4 mockumentary series, The Holden Girls: Mandy & Myrtle.

On 29 June 2022, it was announced that Celebrity Juice had been cancelled by ITV; the series concluded with two specials which aired on 8 and 15 December 2022.