Chelsea is an American late-night talk show hosted by comedian Chelsea Handler. The show debuted on May 11, 2016, and streamed Wednesday, Thursday, and Friday each week worldwide on Netflix. The show was originally set to have 90 episodes per year, with each episode set to be 30 minutes. Format changes were made for the second season. The show taped Monday, Tuesday, and Wednesday of each week that it aired. It was Netflix's first talk show. The theme song was written by electropop artist Memoryy.

The show covered "real topics" mixed with humor, similar to Handler's previous series, Chelsea Does. The show also regularly had celebrity guests. Her comedic partner Chuy was not part of the series. The show had a global outlook; Handler said, "Netflix makes me able to do stories that are global, and it makes me able to pay attention to the stuff that does interest me in a way that will be able to be disseminated into all these different countries."

The second season premiered on April 14, 2017 and consist of 30 episodes .

Unlike the first season, which aired 3 nights a week, the second season aired only once a week. On October 18, 2017, it was announced that the show would not be renewed for a third season.