NBC Nightly News (titled as NBC Nightly News with Lester Holt for its weeknight broadcasts since June 22, 2015) is the flagship daily evening television news program for NBC News, the news division of the NBC television network in the United States. First aired on August 3, 1970, the program is currently the second most watched network newscast in the United States, behind ABC's World News Tonight. NBC Nightly News is produced from Studio 1A at NBC Studios at 30 Rockefeller Center in New York City. Selected Los Angeles–based editions broadcast from The Brokaw News Center in Universal City, California, or when broadcasting from Washington, D.C., either from the NBC News bureau based at WRC-TV in the Tenleytown neighborhood, or NBC's secondary studio overlooking Capitol Hill.

Since 2015, the broadcast has been anchored by Lester Holt on weeknights, José Díaz-Balart on Saturday and Hallie Jackson since 2024 on Sunday. Previous anchors have included John Chancellor, David Brinkley, Tom Brokaw and Brian Williams.

The program is broadcast live over most NBC stations from 6:30 p.m. to 7:00 p.m. Eastern Time seven days a week; the "Western Edition" of the program occasionally features breaking news and/or updated information on news stories covered during the original telecast for Pacific Time Zone viewers, and some stations in that time zone carry it live at 3:30 p.m. PT to lead into their late afternoon local news blocks. Its current theme music, "The Mission", debuted in 1985 and was composed by John Williams.