Disney's House of Mouse (or simply House of Mouse) is an American animated television series produced by Walt Disney Television Animation that originally aired on ABC and Toon Disney from January 13, 2001, to October 24, 2003, with 52 episodes and 22 newly produced cartoon shorts made for the series. The show focuses on Mickey Mouse and his friends running a cartoon theater dinner club in the fictional setting of ToonTown, catering to many characters from Disney cartoons and animated movies while showcasing a variety of their cartoon shorts. The series is named after a common nickname or epithet for the Walt Disney Company.

The animated series is a spin off of the series Mickey Mouse Works, and featured many of the series' shorts as well as selection of brand new shorts, and classic Mickey Mouse, Goofy and Donald Duck shorts from the 1930s–50s.

During its time, the animated series held two nominations for awards, while select cast members won two awards for their performances as characters in House of Mouse. The series featured two direct-to-video films – Mickey's Magical Christmas: Snowed in at the House of Mouse and Mickey's House of Villains – along with an all-night marathon of the House of Mouse, aired on Toon Disney in September 2002 under the title "Night of 1,000 Toons".