WWE SmackDown, also known as Friday Night SmackDown or simply SmackDown, is an American professional wrestling television program produced by WWE. It airs live every Friday at 8 p.m. Eastern Time (ET) on USA Network. SmackDown is the most viewed television show on Friday nights in the United States of America. Fox Deportes simulcasts the program with Spanish-language commentary. The show features characters from the SmackDown brand, to which WWE employees are assigned to work and perform. It is considered to be one of WWE's two flagship programs, along with Monday Night Raw.

SmackDown! debuted in Kemper Arena in Kansas City, Missouri UPN on April 29, 1999, and was formerly broadcast on Thursday nights. The show moved to Friday nights on September 9, 2005, and began airing on The CW in September 2006, after the merger of UPN and the WB. The show later moved to MyNetworkTV in October 2008. On October 1, 2010, SmackDown moved to cable network Syfy, and eventually returned to Thursdays on January 15, 2015. The show then moved to the sibling USA Network on January 7, 2016, and later that year, beginning on July 19, SmackDown began broadcasting live on Tuesday nights. SmackDown's move to Fox on October 4, 2019 marked the show's return to Friday nights and over-the-air broadcast television (as well as the second time SmackDown has aired on a Fox-owned network). On September 13, 2024, the show returned to USA Network.

SmackDown has been broadcast from over 100+ arenas, 100+ cities and towns, and nine countries: United States, Canada, United Kingdom, Japan in 2005, Italy in 2007, Mexico in 2011, and France, Saudi Arabia, and Germany in 2024. Prior to switching to its current live format, taped episodes premiered a few hours earlier in Ireland and the United Kingdom than in the United States (and a day earlier in Australia, Canada, Singapore, and the Philippines) due to time differences. For international broadcast listings, see below. The show celebrated its 15th anniversary on October 10, 2014, and the 1000th episode on October 16, 2018.

The WWE Network ceased operations in the United States on April 4, 2021, with all content moved to Peacock which now has all previous episodes of SmackDown. Recent episodes are still available for on-demand viewing 30 days after the original air date.