Ang Mutya ng Section E (transl. The Jewel of Section E; also known as The Girl of Class E) is a Philippine coming-of-age romantic comedy television series. It is based on the Wattpad book trilogy of the same name by the Filipino author Lara Flores, who is better known by her pseudonym Eatmore2behappy. The series premiered on Viva One on January 3, 2025.

The series stars Ashtine Olviga as Jay-jay, a high school student who transfers to the prestigious Higher Value International School. To her surprise, however, she is sent to Section E, the lowest and most unruly section of the school. The boys of Section E, especially the class president Keifer, are determined to drive their only female classmate out of their section, but she won't go down without a fight.