Karen Sisco is an American crime drama television series starring Carla Gugino in the title role. The series was created by novelist Elmore Leonard, based on a character who had appeared in several of his written works, as well as one film adaptation, 1998's Out of Sight. The series debuted on October 1, 2003 on ABC, and was canceled after ten episodes, with Gugino later reprising her role from the series in a 2012 third season episode of Justified.

As a U.S. Deputy Marshal, based on Miami, Florida's Gold Coast, Karen must deal with the underbelly of South Beach nightlife and Palm Beach high life while tracking down fugitives. She also struggles to win the respect of her fellow officers. Karen occasionally gets advice from her father, a retired Miami police officer turned private investigator, who is Karen’s confidant, counselor, and confessor. The show faced stiff competition from NBC's Law & Order.

TV Guide included the series in their 2013 list of 60 shows that were "Canceled Too Soon".