The Ellen DeGeneres Show is an American first-run syndicated talk show that was hosted by Ellen DeGeneres. The show ran for nineteen seasons from September 8, 2003, to May 26, 2022, in which it broadcast 3,339 episodes. It was produced by Telepictures Productions. The majority of stations owned by NBC Owned Television Stations, along with Hearst Television and Tegna, served as the program's largest affiliate base. For its first five seasons, the show was taped in Studio 11 at NBC Studios in Burbank, California. From season 6 onwards, the show moved to being taped at Stage 1 on the nearby Warner Bros. lot. Since the beginning of the sixth season, The Ellen DeGeneres Show was broadcast in high definition.

The show received 171 Daytime Emmy Award nominations and won 63 Daytime Emmy Awards as of 2022, including four for Outstanding Talk Show and seven for Outstanding Talk Show Entertainment, making 11 total awards and surpassing the record held by The Oprah Winfrey Show, which won nine as Outstanding Talk Show before it was divided into two categories (Informative and Entertainment) in 2008. The show also won 17 People's Choice Awards. On May 21, 2019, DeGeneres announced she had signed for three more years, renewing the show through 2022. The eighteenth season premiered on September 21, 2020. On May 12, 2021, DeGeneres announced that the nineteenth season would be her last, which premiered on September 13, 2021.

The final episode aired on May 26, 2022, as previously announced on March 17, 2022. New episodes with guest hosts, clip shows hosted by DeGeneres and more, and repeats aired on stations across the United States until September 9, after which most stations (including NBC O&O) began occupying the show's time slot with new newscasts or syndication programs such as The Kelly Clarkson Show.